Deproteinized Bone Tissue as a Matrix for Tissue-Engineered Construction: Experimental Study

Background. At present, for a number of reasons the complete bone defect replacement with autogenous is not always possible. Bone substitute materials are used as an alternative to tissue and can be either biological or non-biological origin. One ways development reconstructive technologies use tissue-engineered constructs that fully imitate in required volume.
 Aim study define vivo possibility using deproteinized human cancellous matrix creating constructs.
 Methods. An was carried out on NZW rabbits. To create construct, we fragments femoral head stromal vascular fraction rabbit adipose matrix. modeling its subsequent performed evaluate efficacy reparative osteogenesis during defects reconstruction. Study groups were defined: group 1 (control) surgical femur without reconstruction; 2 reconstruction matrix; 3 combination (according ACP SVF technology).
 Results. Comparative analysis processes case applying based tissue-derived experimental model revealed these contributes only early activation regeneration main structural elements area replacement, but also well-timed differentiation. This determines restoration functional viability at damage site developing discernible reactive inflammation. Moreover, effect selected construct combined influence several factors (ACP SVF) composition turned more effective stimulating repair differentiation.
 Conclusion. Combination enables engage mechanisms accelerate process comparison isolated